NIH Blueprint: The Human Connectome Project

News and Updates

Press Releases,Project News | August 27, 2014

Data from Multiple Projects now being shared on ConnectomeDB

The Human Connectome Project (HCP) WU-Minn consortium is pleased to announce an update to ConnectomeDB to support open access distribution of data and documentation for HCP-related projects beyond and in addition to the main WU-Minn HCP dataset.

Multi-projectsDB2What’s changed in the ConnectomeDB interface? You will notice that ConnectomeDB has gotten a bit of a facelift, but the changes are not difficult to navigate. Upon login to ConnectomeDB, users are taken to the Public Connectome Data page, listing multiple projects with released HCP-related data (the WU-Minn HCP 500 Subjects dataset released in June 2014 is listed first).

Select a project using the pulldown at the top left, or by clicking on a Project’s title. Once you are on a Project-specific page, note that selection of subject groups, download options, and browse subjects  (opening the Subject Dashboard) have moved to buttons on the top right.

Along with these updates, we are releasing datasets from two projects:

WU-Minn HCP Lifespan Pilot Study

Multimodal (T1w/T2w, rfMRI, tfMRI, and dMRI) imaging pilot data acquired across the lifespan, in 6 age groups (4-6, 8-9, 14-15, 25-35, 45-55, 65-75) using scanners that differ in field strength (3T, 7T) and maximum gradient strength (70-100 mT/m). Click for more information on data acquisition for Phase 1a and Phase 1b of the WU-Minn HCP Lifespan Pilot Study.

What’s in the WU-Minn HCP Lifespan Pilot initial data release? This initial release of WU-Minn HCP Lifespan Pilot data includes unprocessed data from Phase 1a, which includes multimodal data from 27 total subjects in 5 age groups (8-9, 14-15, 25-35, 45-55, 65-75). Unprocessed NIFTI images plus unprocessed data corrected for gradient nonlinearity distortion are available for download as a single data package for each modality that includes data from all 27 subjects (351 GB total) or as user-defined groups using filtering on the Subject Dashboard (go to “Explore Subjects” in the Lifespan Pilot Dataset). Access to the WU-Minn HCP Lifespan Pilot data is covered by the WU-Minn HCP Data Use Terms and does not require additional agreement.

MGH-USC HCP Diffusion Study

Diffusion and structural imaging data acquired from 35 adults (aged 20-59) using the customized MGH Siemens 3T Connectom scanner, which has 300 mT/m maximum gradient strength for diffusion imaging.

What’s in the MGH-USC HCP Adult Diffusion data release?  This release of data from the MGH-USC Human Connectome Project includes preprocessed structural and diffusion data acquired from 35 unrelated healthy adults (ages 20-59) using the MGH Siemens 3T Connectom scanner customized for high sensitivity and contrast diffusion imaging, as detailed in Setsompop et al., 2013. None of the subjects are the same as those scanned by WU-Minn HCP. Data may be downloaded in packages for each subject (6.8 GB), a group of 5 subjects (34 GB), or all subjects (237 GB). Access to the MGH-USC HCP Adult Diffusion data requires electronic agreement to a separate set of Data Use Terms.

Access Multiple project HCP data on the HCP website. Explore and download the above datasets via the ConnectomeDB database. Note: Please clear your browser cache before logging in to ConnectomeDB.

Have more questions?  If you are actively using HCP data and tools, we encourage you send your questions to and join the hcp-users discussion group (, so that you can tune in to technical discussions on issues that may be of interest.

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Posted by Jenn Elam @ 1:27 pm

Project News | July 24, 2014

NIH Funding Opportunity on Connectomes Related to Human Disease

nih-oer-logoNIH recently announced a funding opportunity PAR-14-281: Connectomes Related to Human Disease (U01) for projects that will:

“apply the Human Connectome data collection protocol to disease/disorder cohorts of interest to the Institutes and Centers that are participating in this FOA.”

The announcement indicates that projects are expected to emulate HCP preprocessing pipelines and to share imaging and behavioral data via the Connectome Coordination Facility to be established at Washington University.

For additional information relevant to meeting these conditions for data acquisition, processing, and sharing, please see HCP Disease-related Connectome FAQ.

Press Releases,Project News | June 9, 2014

HCP Announces Release of Data from 500 Subjects

The Human Connectome Project (HCP) WU-Minn consortium is pleased to announce the release of 500 Subjects of HCP image and behavioral data.

hcp-announce-500sWhat’s in the HCP 500 Subjects data release? The 500 Subjects release includes behavioral/demographic and 3T MR imaging data from 523 healthy adult participants collected in Q1-Q6. Structural scans are available for over 500 subjects. Over 440 subjects completed all of the four imaging modalities in the HCP protocol: structural images (T1w and T2w), resting-state fMRI (rfMRI), task fMRI (tfMRI), and high angular resolution diffusion imaging (dMRI). In addition to MR scans, 14 subjects were also scanned in resting-state MEG (rMEG) and task MEG (tMEG).

The 500 Subjects release also includes:

Significant updates for MR minimal preprocessing pipelines. Changes have been made to all of the HCP minimal preprocessing pipelines, including a switch to MSMSulc registration from FreeSurfer registration in structural MR pipeline, component analysis software updates (FSL 5.0.6, FreeSurfer 5.3.0-HCP, Connectome Workbench beta v0.85), output files in CIFTI-2.0 format, . An update to the CIFTI file format was released in March 2014 (see for details). All CIFTI files produced by the HCP pipelines are now in CIFTI-2.0 format.

Individual task fMRI analysis results available at various surface smoothing levels.  Individual (within-subject) grayordinates (surface)-based cross run level-2 tfMRI analysis results using FSL are now available at several levels of total smoothing: 2mm, 4mm, 8mm, and 12mm smoothed on the surface. 4mm volume-smoothed cross run tfMRI analysis results are also available.

Updates to MEG data and access in ConnectomeDB. Cortical sheet based anatomical source models are now available, MEG data have been integrated into the ConnectomeDB dashboard, and MR data is now available for all released MEG subjects.

Group-average functional MR data for two larger subject groups. Resting state functional connectivity MRI (fcMRI) correlation matrices (“dense” functional connectome files), in full correlation matrix and mean gray signal regressed versions are available for a group of 468 ‘related’ subjects (R468) with complete rfMRI data. Task functional MRI (tfMRI) contrasts are available using data processed with the updated processing pipelines for two groups: 100 unrelated (U100) subjects and 400+ ‘related’ subjects (R400+) that are a mixture of related and unrelated subjects.

Additional restricted behavioral and demographic data. Restricted data has been added for all subjects from alcohol and tobacco 7-day retrospective surveys; demographic, mental health, and substance use data from the semi-structured assessment for the genetics of alcoholism (SSAGA) interview; physical health and history measures; menstrual cycle information on female subjects; and family history of psychiatric illness.

Improvements to behavioral data organization and data dictionary. We have reorganized fields, renamed variables, and improved descriptions for behavioral and individual difference data to make navigation and filtering more intuitive in ConnectomeDB.

All imaging data soon to be available on the cloud through Amazon S3. HCP has partnered with Amazon Web Services Amazon Web Services (AWS) Public Data Sets program ( to offer storage and access to all HCP imaging data on Amazon S3 within weeks of the 500 Subjects Release.

Access 500 Subjects data on the HCP website. Explore, download, or order the HCP 500 Subjects dataset (~17TB of data!) via the ConnectomeDB database. Most HCP image and behavioral data is openly accessible to investigators worldwide who register and accept a limited set of Open Access Data Use Terms. Note: Please clear your browser cache before logging in to ConnectomeDB.

Want more information?  Check out the HCP 500 Subjects Release Reference Manual for a comprehensive guide that includes details on imaging protocols, behavioral measures, and information that will help users obtain and analyze the 500 Subjects data.

If you are actively using HCP data and tools, we encourage you to join and be active in the hcp-users discussion group (, so that you can tune in to technical discussions on issues that may be of interest.

Thanks again for your interest in the HCP.  Please send us your questions and comments anytime to

Posted by Jenn Elam @ 8:21 am
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