Changes in brain structure and function are a normal part of the aging process from middle age through older adulthood. In the last decade, an explosion of work has focused on brain structure in disorders that occur as we age. Yet, relatively few studies have focused on healthy aging of brain circuitry and how it varies across people.
Thanks to recent technological advances pioneered by the Human Connectome Project study of healthy young adults, we can now explore how the brain typically ages and how connections change in mature and older adults. Data collected will be shared broadly so that researchers can learn as much as possible from it for years to come. Characterizing brain aging in healthy adults will also allow us to better understand differences in people with conditions that may affect brain wiring such as dementia or major depression.
Ultimately, the HCP-A Study aims to collect information that we, our families, and health professionals can use to enhance our well being as we age.
The Lifespan Human Connectome Project Aging (HCP-A) Study will enroll 1,500+ healthy adults ages 36-100+ to discover how individual experiences affect the ways in which different parts of the brain are connected and how these connections (the “connectome”) change across healthy adulthood. To learn how to participate, go to our Recruitment Page.
Lifespan HCP Release 1.0 Data includes unprocessed data of all modalities (structural MRI, resting state fMRI, task fMRI, and diffusion MRI) for 600+ subjects each from HCP-A and HCP-D and minimally preprocessed structural MRI data (only) for 129 HCP-A and 84 HCP-D subjects, respectively.
Data is available in the NIMH Data Archive. See our documentation for access instructions.
Release Date: May 21, 2019