PDC Release 1.0 of imaging and behavioral data is now available in the NIMH Data Archive (NDA). Perturbation of the depression connectome by fast-acting therapies (Perturbation of the Depression Connectome, PDC) is a study of adults with and without treatment resistant depression (191 patients, 51 controls) and with and without fast-acting treatment interventions (ages 20-64, with treatment-resistant depression treated with ECT [N=44], ketamine [N=67], or total sleep deprivation [N=60], plus healthy controls [N=51]). Of the healthy controls, 16 underwent total sleep deprivation and 17 were assessed at 2 visits without intervention.
 

PDC Release 1.0 data includes: 

• unprocessed data of all modalities (structural MRI, resting state fMRI, task fMRI for 2 tasks, and diffusion MRI) for 227 subjects
• minimally preprocessed MRI data of all modalities for up to 218 subjects
• clinical and behavioral data for 230 subjects 

Get Access and Download the data: Get started with the Data Access and Download Instructions for obtaining access, navigating NDA and using it's download tools. We've also created a wiki that details setup steps  for downloading data via NDA's command line tools.

The released data are available on NDA as:

• PDCRec package of recommended preprocessed + behavioral data (1076 GB, OPTION ONE)
• PDCAllFiles package of all released imaging and behavioral data (9.5 TB, OPTION ONE)
• PDCImgManifestBeh  package of imaging manifests + behavioral data (332 MB, OPTION ONE)
• or can be filtered on to create a custom package of a subset of the data (OPTION TWO).

Want more information?  Check out our documentation to help with understanding the project and interpreting the data.