Perturbation of the Treatment of Resistant Depression Connectome by Fast-Acting Therapies (PDC)

Imaging Protocols for PDC

There are 3 protocol versions in a single PDF (HCP_MDD_020917) that vary slightly according to which treatment cohort:

1. HCP_KET

This was the protocol for subjects receiving ketamine treatment.  The difference to the protocol is that it included a MRS (svs_edit_859G_WS, svs_edit_859G_NWS) acquisition.  We did not do the MRS scan for the last ~10 subjects.

2. HCP_TSD_ECT

This was the protocol for subjects receiving ECT or TSD (including TSD patients and TSD controls) and controls if scanned twice.  This is the same as the ketamine protocol but without MRS.

3. HCP_CON

This was the protocol used for control subjects scanned only once.  It is the same as HCP_TSD_ECT except that we did another set of resting state scans.  The rationale was that resting state scans could be concatenated across time point for subjects scanned more than once for the purpose of functional segmentation, but some controls were only budgeted for one scan.

Further Reading:

Tozzi, L., Anene, E. T., Gotlib, I. H., Wintermark, M., Kerr, A. B., Wu, H., Seok, D., Narr, K. L., Sheline, Y. I., Whitfield-Gabrieli, S., & Williams, L. M. (2021). Convergence, preliminary findings and future directions across the four human connectome projects investigating mood and anxiety disorders. NeuroImage, 245, 118694. https://doi.org/10.1016/j.neuroimage.2021.118694

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