Dimensional Connectomics of Anxious Misery

Project Overview & Components

Data being collected

  • Imaging:  This project will use the 2-session HCP Lifespan protocol implemented on a single Siemens 3T Prisma MRI scanner.  Scans will begin with background-suppressed pseudo-continuous arterial spin labeling (pCASL) to quantify whole-brain cerebral blood flow.  In addition to standard HCP Lifespan task-based fMRI data for working memory, face recognition, social cognition, and gambling, we will add a task-fMRI acquisition designed to measure implicit emotional conflict.  Finally, an optimized T2-weighted image sequence with ultra-high in-plane resolution will be acquired through the temporal lobe for use in hippocampal and amygdala segmentations.
  • Clinical: Neuropsychological testing, multiple phenotypic measures including the SCID.
  • Genetics: blood samples and/or saliva samples.
  • Behavioral: Neurocognitive data using the NIH Toolbox and Penn Computerized Neurocognitive Battery, results from startle task, and self-reporting of mood. 

Cohort Description

This study will recruit 50 control participants and 200 participants with anxious misery symptoms from the Outpatient Clinics of the University of Pennsylvania. All subjects will be 18-45, male or female, any race, and English speaking. Likewise, all subjects will have the capacity to give informed consent and follow study procedures.  Participants will be recruited to the University of Pennsylvania, where they will undergo an extensive multi-modal assessment to characterize the cross-sectional phenomenology of these Negative Valence domains and a one-year follow up to assess subsequent symptoms. 

Data Release Plans

Analyzed data on all subjects, gathered up to that point, will be released during year 2 of the project.  Analyzed data for all 250 subjects will be released at the conclusion of the study in year 4. 


Human Connectome Project, Negative Valence System, Anxious Misery, Brain Imaging